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The Lefler Center

for the study of Neurodegenerative Diseases


Lefler grantees have made some groundbreaking discoveries. The portfolio of Lefler Center research ranges from high-resolution molecular studies, to new insights into cellular functions, circuit mapping in the brain, and has even led to the discovery of new analgesics. Each discovery contributes a piece to a complex puzzle. Together, they describe the landscape of brain function, the fundamental basis for understanding nervous system disease. The following list of selected publications provides a glimpse at the output of our community of gifted researchers, demonstrating the value of convening an interdisciplinary research community dedicated to a common goal.


Abraira VE, Kuehn ED, Chirila AM, Springel MW, Toliver AA, Zimmerman AL, Orefice LL, Boyle KA, Bai L, Song BJ, Bashista KA, O’Neill TG, Zhuo J, Tsan C, Hoynoski J, Rutlin M, Kus L, Niederkofler V, Watanabe M, Dymecki SM, Nelson SB, Heintz N, Hughes DI, Ginty DD. The Cellular and Synaptic Architecture of the Mechanosensory Dorsal Horn. Cell. 2017;168(1-2):295-310.e19. doi:10.1016/j.cell.2016.12.010.

Ade KK, Janssen MJ, Ortinski PI, Vicini S, Wan Y, Chen M, et al. Differential Tonic GABA Conductances in Striatal Medium Spiny Neurons. Journal of Neuroscience. 2008;28(5):1185-97. doi: 10.1523/JNEUROSCI.3908-07.2008.

Almasi S, Xu X, Ben-Zvi A, Lacoste B, Gu C, Miller EL. A novel method for identifying a graph-based representation of 3-D microvascular networks from fluorescence microscopy image stacks. Medical image analysis. 2015;20(1):208-23. doi: 10.1016/

Andreone BJ, Chow BW, Tata A, Lacoste B, Ben-Zvi A, Bullock K, Deik AA, Ginty DD, Clish CB, Gu C. Blood-Brain Barrier Permeability Is Regulated by Lipid Transport-Dependent Suppression of Caveolae-Mediated Transcytosis. Neuron. 2017 May 3;94(3):581-594.e5. doi: 10.1016/j.neuron.2017.03.043. 

Antal M, Beneduce BM, Regehr WG. The Substantia Nigra Conveys Target-Dependent Excitatory and Inhibitory Outputs from the Basal Ganglia to the Thalamus. Journal of Neuroscience. 2014;34(23):8032-42. doi: 10.1523/JNEUROSCI.0236-14.2014.

Aryal RP, Kwak PB, Tamayo AG, Gebert M, Chiu PL, Walz T, et al. Macromolecular Assemblies of the Mammalian Circadian Clock. Mol Cell. 2017;67(5):770-82 e6. Epub 2017/09/09. doi: 10.1016/j.molcel.2017.07.017. PubMed PMID: 28886335; PubMed Central PMCID: PMCPMC5679067.

Aviles EC, Goodrich LV. Configuring a robust nervous system with Fat cadherins. Semin Cell Dev Biol. 2017;69:91-101. Epub 2017/06/13. doi: 10.1016/j.semcdb.2017.06.001. PubMed PMID: 28603077; PubMed Central PMCID: PMCPMC5582996.

Azim E, Shnider SJ, Cederquist GY, Sohur US, Macklis JD. Lmo4 and Clim1 progressively delineate cortical projection neuron subtypes during development. Cerebral cortex (New York, NY : 1991). 2009;19 Suppl 1:i62-9. doi: 10.1093/cercor/bhp030.

Bai L, Lehnert BP, Liu J, Neubarth NL, Dickendesher TL, Nwe PH, Cassidy C, Woodbury CJ, Ginty DD. Genetic Identification of an Expansive Mechanoreceptor Sensitive to Skin Stroking. Cell. 2015;163(7):1783-1795. doi:10.1016/j.cell.2015.11.060.

Baizabal JM, Mistry M, Garcia MT, Gomez N, Olukoya O, Tran D, et al. The Epigenetic State of PRDM16-Regulated Enhancers in Radial Glia Controls Cortical Neuron Position. Neuron. 2018. Epub 2018/05/22. doi: 10.1016/j.neuron.2018.04.033. PubMed PMID: 29779941

Bear DM, Lassance JM, Hoekstra HE, Datta SR. The Evolving Neural and Genetic Architecture of Vertebrate Olfaction. Curr Biol. 2016;26(20):R1039-R49. Epub 2016/10/26. doi: 10.1016/j.cub.2016.09.011. PubMed PMID: 27780046; PubMed Central PMCID: PMCPMC5104188.

Berger Z, Smith KA, Lavoie MJ. Membrane localization of LRRK2 is associated with increased formation of the highly active LRRK2 dimer and changes in its phosphorylation. Biochemistry. 2010;49(26):5511-23. doi: 10.1021/bi100157u.

Biffi A, Plourde A, Shen Y, Onofrio R, Smith EE, Frosch M, et al. Screening for familial APP mutations in sporadic cerebral amyloid angiopathy. PloS one. 2010;5(11):e13949-e. doi: 10.1371/journal.pone.0013949.

Browne LE, Latremoliere A, Lehnert BP, Grantham A, Ward C, Alexandre C, Costigan M, Michoud F, Roberson DP, Ginty DD, Woolf CJ.  Time-Resolved Fast Mammalian Behavior Reveals the Complexity of Protective Pain Responses. Cell Rep. 2017 Jul 5;20(1):89-98. doi: 10.1016/j.celrep.2017.06.024.

Cao L, Rickenbacher GT, Rodriguez S, Moulia TW, Albers MW. The precision of axon targeting of mouse olfactory sensory neurons requires the BACE1 protease. Scientific reports. 2012;2:231-. doi: 10.1038/srep00231.

Chen L, Periquet M, Wang X, Negro A, McLean PJ, Hyman BT, et al. Tyrosine and serine phosphorylation of alpha-synuclein have opposing effects on neurotoxicity and soluble oligomer formation. The Journal of clinical investigation. 2009;119(11):3257-65. doi: 10.1172/JCI39088.

Chen Y, Granger AJ, Tran T, Saulnier JL, Kirkwood A, Sabatini BL. Endogenous Galphaq-Coupled Neuromodulator Receptors Activate Protein Kinase A. Neuron. 2017;96(5):1070-83 e5. Epub 2017/11/21. doi: 10.1016/j.neuron.2017.10.023. PubMed PMID: 29154125; PubMed Central PMCID: PMCPMC5726796.

DaRocha-Souto B, Coma M, Pérez-Nievas BG, Scotton TC, Siao M, Sánchez-Ferrer P, et al. Activation of glycogen synthase kinase-3 beta mediates β-amyloid induced neuritic damage in Alzheimer’s disease. Neurobiology of disease. 2012;45(1):425-37. doi: 10.1016/j.nbd.2011.09.002.

Dashkoff J, Lerner EP, Truong N, Klickstein JA, Fan Z, Mu D, et al. Tailored transgene expression to specific cell types in the central nervous system after peripheral injection with AAV9. Molecular Therapy – Methods & Clinical Development. 2016;3:16081-. doi: 10.1038/mtm.2016.81.

Davies SE, Hallett PJ, Moens T, Smith G, Mangano E, Kim HT, et al. Enhanced ubiquitin-dependent degradation by Nedd4 protects against α-synuclein accumulation and toxicity in animal models of Parkinson’s disease. Neurobiology of disease. 2014;64:79-87. doi: 10.1016/j.nbd.2013.12.011.

de Jong APH, Roggero CM, Ho MR, Wong MY, Brautigam CA, Rizo J, et al. RIM C2B Domains Target Presynaptic Active Zone Functions to PIP2-Containing Membranes. Neuron. 2018;98(2):335-49 e7. Epub 2018/04/03. doi: 10.1016/j.neuron.2018.03.011. PubMed PMID: 29606581; PubMed Central PMCID: PMCPMC5910229.

Del Rio T, Nishitani AM, Yu W-M, Goodrich LV. In vivo analysis of Lrig genes reveals redundant and independent functions in the inner ear. PLoS genetics. 2013;9(9):e1003824-e. doi: 10.1371/journal.pgen.1003824.

Ding JB, Oh W-J, Sabatini BL, Gu C. Semaphorin 3E-Plexin-D1 signaling controls pathway-specific synapse formation in the striatum. Nature neuroscience. 2012;15(2):215-23. doi: 10.1038/nn.3003.

Dissing-Olesen L, Hong S, Stevens B. New Brain Lymphatic Vessels Drain Old Concepts. EBioMedicine. 2015;2(8):776-7. doi: 10.1016/j.ebiom.2015.08.019.

Driscoll LN, Pettit NL, Minderer M, Chettih SN, Harvey CD. Dynamic Reorganization of Neuronal Activity Patterns in Parietal Cortex. Cell. 2017 Aug 24;170(5):986-999.e16. doi: 10.1016/j.cell.2017.07.021.

Duong HA, Weitz CJ. Temporal orchestration of repressive chromatin modifiers by circadian clock Period complexes. Nat Struct Mol Biol. 2014;21(2):126-32. Epub 2014/01/15. doi: 10.1038/nsmb.2746. PubMed PMID: 24413057; PubMed Central PMCID: PMCPMC4227600.

Farrar CT, William CM, Hudry E, Hashimoto T, Hyman BT. RNA aptamer probes as optical imaging agents for the detection of amyloid plaques. PLoS one. 2014;9(2):e89901-e. doi: 10.1371/journal.pone.0089901.

Fioravante D, Chu Y, de Jong AP, Leitges M, Kaeser PS, Regehr WG. Retraction: Protein kinase C is a calcium sensor for presynaptic short-term plasticity. Elife. 2018;7. Epub 2018/03/08. doi: 10.7554/eLife.35974. PubMed PMID: 29512487; PubMed Central PMCID: PMCPMC5849408.

Fitzgerald JK, Freedman DJ, Fanini A, Bennur S, Gold JI, Assad JA. Biased associative representations in parietal cortex. Neuron. 2013;77(1):180-91. doi: 10.1016/j.neuron.2012.11.014.

Frank MM, Goodrich LV. Talking back: Development of the olivocochlear efferent system. Wiley Interdiscip Rev Dev Biol. 2018:e324. Epub 2018/06/27. doi: 10.1002/wdev.324. PubMed PMID: 29944783.

Freedman DJ, Assad JA. Neuronal Mechanisms of Visual Categorization: An Abstract View on Decision Making. Annu Rev Neurosci. 2016;39:129-47. Epub 2016/04/14. doi: 10.1146/annurev-neuro-071714-033919. PubMed PMID: 27070552.

Fricker-Gates RA, Shin JJ, Tai CC, Catapano LA, Macklis JD. Late-stage immature neocortical neurons reconstruct interhemispheric connections and form synaptic contacts with increased efficiency in adult mouse cortex undergoing targeted neurodegeneration. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2002;22(10):4045-56. doi: 20026384.

Galea E, Morrison W, Hudry E, Arbel-Ornath M, Bacskai BJ, Gómez-Isla T, et al. Topological analyses in APP/PS1 mice reveal that astrocytes do not migrate to amyloid-β plaques. Proceedings of the National Academy of Sciences of the United States of America. 2015;112(51):15556-61. doi: 10.1073/pnas.1516779112.

Garcia-Alloza M, Prada C, Lattarulo C, Fine S, Borrelli LA, Betensky R, et al. Matrix metalloproteinase inhibition reduces oxidative stress associated with cerebral amyloid angiopathy in vivo in transgenic mice. Journal of neurochemistry. 2009;109(6):1636-47. doi: 10.1111/j.1471-4159.2009.06096.x.

Garcia-Alloza M, Robbins EM, Zhang-Nunes SX, Purcell SM, Betensky RA, Raju S, et al. Characterization of amyloid deposition in the APPswe/PS1dE9 mouse model of Alzheimer disease. Neurobiology of disease. 2006;24(3):516-24. doi: 10.1016/j.nbd.2006.08.017.

Gates MA, Fricker-Gates RA, Macklis JD. Reconstruction of cortical circuitry. Progress in brain research. 2000;127:115-56.

Gelfand MV, Hagan N, Tata A, Oh W-J, Lacoste B, Kang K-T, et al. Neuropilin-1 functions as a VEGFR2 co-receptor to guide developmental angiogenesis independent of ligand binding. eLife. 2014;3:e03720-e. doi: 10.7554/eLife.03720.

Gierdalski M, Sardi SP, Corfas G, Juliano SL. Endogenous neuregulin restores radial glia in a (ferret) model of cortical dysplasia. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2005;25(37):8498-504. doi: 10.1523/JNEUROSCI.1476-05.2005.

Gillis WF, Datta SR. Knowing where the nose is. BMC Biol. 2017;15(1):42. Epub 2017/05/17. doi: 10.1186/s12915-017-0382-6. PubMed PMID: 28506236; PubMed Central PMCID: PMCPMC5432980

Greenberg SM, Grabowski T, Gurol ME, Skehan ME, Nandigam RNK, Becker JA, et al. Detection of isolated cerebrovascular beta-amyloid with Pittsburgh compound B. Annals of neurology. 2008;64(5):587-91. doi: 10.1002/ana.21528.

Greer Paul L, Bear Daniel M, Lassance J-M, Bloom Maria L, Tsukahara T, Pashkovski Stan L, et al. A Family of non-GPCR Chemosensors Defines an Alternative Logic for Mammalian Olfaction. Cell. 2016;165(7):1734-48. doi: 10.1016/j.cell.2016.05.001.

Gregory JL, Prada CM, Fine SJ, Garcia-Alloza M, Betensky RA, Arbel-Ornath M, et al. Reducing available soluble β-amyloid prevents progression of cerebral amyloid angiopathy in transgenic mice. Journal of neuropathology and experimental neurology. 2012;71(11):1009-17. doi: 10.1097/NEN.0b013e3182729845.

Gross GG, Straub C, Perez-Sanchez J, Dempsey WP, Junge JA, Roberts RW, et al. An E3-ligase-based method for ablating inhibitory synapses. Nature methods. 2016;13(8):673-8. doi: 10.1038/nmeth.3894.

Gyorgy B, Sage C, Indzhykulian AA, Scheffer DI, Brisson AR, Tan S, et al. Rescue of Hearing by Gene Delivery to Inner-Ear Hair Cells Using Exosome-Associated AAV. Mol Ther. 2017;25(2):379-91. Epub 2017/01/14. doi: 10.1016/j.ymthe.2016.12.010. PubMed PMID: 28082074; PubMed Central PMCID: PMCPMC5368844

Hamouda, AK, Kimm, T, Cohen, JB (2013) Physostigmine and galanthamine bind in the presence of agonist at the canonical and non-canonical subunit interfaces of a nicotinic acetylcholine receptor. J. Neuroscience 33:485-494. doi: 10.1523/JNEUROSCI.3483-12.2013.

Hamouda, AK, Wang, ZJ, Stewart, DA, Jain, AD, Glennon, RA, Cohen, JB (2015) Desformylflustrabromine (dFBr) and [3H]dFBr-labeled binding sites in a nicotinic acetylcholine receptor. Mol. Pharmacol. 88: 1-11. doi: 10.1124/mol.115.098913.

Hamouda, AK, Deba, F, Wang, ZJ, Cohen, JB (2016) Photolabeling a nicotinic acetylcholine receptor (nAChR) with an (α4)3(β2)2 nAChR-selective positive allosteric modulator. Mol. Pharmacol. 89:575-584. doi: 10.1124/mol.116.103341.

Harper JW, Ordureau A, Heo JM. Building and decoding ubiquitin chains for mitophagy. Nat Rev Mol Cell Biol. 2018;19(2):93-108. Epub 2018/01/24. doi: 10.1038/nrm.2017.129. PubMed PMID: 29358684

Hong YK, Park S, Litvina EY, Morales J, Sanes JR, Chen C. Refinement of the retinogeniculate synapse by bouton clustering. Neuron. 2014;84(2):332-9. Epub 2014/10/07. doi: 10.1016/j.neuron.2014.08.059. PubMed PMID: 25284005; PubMed Central PMCID: PMCPMC4322918.

Hong S, Beja-Glasser VF, Nfonoyim BM, Frouin A, Li S, Ramakrishnan S, et al. Complement and microglia mediate early synapse loss in Alzheimer mouse models. Science (New York, NY). 2016;352(6286):712-6. doi: 10.1126/science.aad8373.

Hong S, Stevens B. Microglia: Phagocytosing to Clear, Sculpt, and Eliminate. Developmental cell. 2016;38(2):126-8. doi: 10.1016/j.devcel.2016.07.006.

Hong S, Stevens B. TREM2: Keeping Microglia Fit during Good Times and Bad. Cell metabolism. 2017;26(4):590-1. Epub 2017/10/06. doi: 10.1016/j.cmet.2017.09.010. PubMed PMID: 28978423.

Hori Y, Takeda S, Cho H, Wegmann S, Shoup TM, Takahashi K, et al. A Food and Drug Administration-approved asthma therapeutic agent impacts amyloid β in the brain in a transgenic model of Alzheimer disease. The Journal of biological chemistry. 2015;290(4):1966-78. doi: 10.1074/jbc.M114.586602.

Hou XH, Hyun M, Taranda J, Huang KW, Todd E, Feng D, et al. Central Control Circuit for Context-Dependent Micturition. Cell. 2016;167(1):73-86 e12. Epub 2016/09/24. doi: 10.1016/j.cell.2016.08.073. PubMed PMID: 27662084.

Huang S, O’Donovan KJ, Turner EE, Zhong J, Ginty DD. Extrinsic and intrinsic signals converge on the Runx1/CBFβ transcription factor for nonpeptidergic nociceptor maturation. Elife. 2015;4:e10874. doi:10.7554/eLife.10874.

Hudry E, Martin C, Gandhi S, György B, Scheffer DI, Mu D, et al. Exosome-associated AAV vector as a robust and convenient neuroscience tool. Gene therapy. 2016;23(4):380-92. doi: 10.1038/gt.2016.11.

Hudry E, Dashkoff J, Roe AD, Takeda S, Koffie RM, Hashimoto T, et al. Gene transfer of human Apoe isoforms results in differential modulation of amyloid deposition and neurotoxicity in mouse brain. Science translational medicine. 2013;5(212):212ra161-212ra161. doi: 10.1126/scitranslmed.3007000.

Hudry E, Wu H-Y, Arbel-Ornath M, Hashimoto T, Matsouaka R, Fan Z, et al. Inhibition of the NFAT pathway alleviates amyloid β neurotoxicity in a mouse model of Alzheimer’s disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2012;32(9):3176-92. doi: 10.1523/JNEUROSCI.6439-11.2012.

Iurilli G, Datta SR. Population Coding in an Innately Relevant Olfactory Area. Neuron. 2017;93(5):1180-97 e7. Epub 2017/02/28. doi: 10.1016/j.neuron.2017.02.010. PubMed PMID: 28238549; PubMed Central PMCID: PMCPMC5370575.

Hyman BT, Growdon JH, Albers MW, Buckner RL, Chhatwal J, Gomez-Isla MT, et al. Massachusetts Alzheimer’s Disease Research Center: progress and challenges. Alzheimer’s & dementia : the journal of the Alzheimer’s Association. 2015;11(10):1241-5. doi: 10.1016/j.jalz.2015.06.1887.

Jackman SL, Chen CH, Chettih SN, Neufeld SQ, Drew IR, Agba CK, et al. Silk Fibroin Films Facilitate Single-Step Targeted Expression of Optogenetic Proteins. Cell Rep. 2018;22(12):3351-61. Epub 2018/03/22. doi: 10.1016/j.celrep.2018.02.081. PubMed PMID: 29562189; PubMed Central PMCID: PMCPMC5894120.

Jha RM, Liu X, Chrenek R, Madsen JR, Cardozo DL. The Postnatal Human Filum Terminale Is a Source of Autologous Multipotent Neurospheres Capable of Generating Motor Neurons. Neurosurgery. 2013;72(1):118-29. doi: 10.1227/NEU.0b013e318276b445.

Jin J, Wu L-J, Jun J, Cheng X, Xu H, Andrews NC, et al. The channel kinase, TRPM7, is required for early embryonic development. Proceedings of the National Academy of Sciences of the United States of America. 2012;109(5):E225-33. doi: 10.1073/pnas.1120033109.

Junge HJ, Yung AR, Goodrich LV, Chen Z. Netrin1/DCC signaling promotes neuronal migration in the dorsal spinal cord. Neural Dev. 2016 Oct 26;11(1):19.

Kim J, Oh W-J, Gaiano N, Yoshida Y, Gu C. Semaphorin 3E-Plexin-D1 signaling regulates VEGF function in developmental angiogenesis via a feedback mechanism. Genes & development. 2011;25(13):1399-411. doi: 10.1101/gad.2042011.

Kim JY, Kwak PB, Gebert M, Duong HA, Weitz CJ. Purification and analysis of PERIOD protein complexes of the mammalian circadian clock. Methods Enzymol. 2015;551:197-210. Epub 2015/02/11. doi: 10.1016/bs.mie.2014.10.013. PubMed PMID: 25662458.

Kim JY, Kwak PB, Weitz CJ. Specificity in circadian clock feedback from targeted reconstitution of the NuRD corepressor. Mol Cell. 2014;56(6):738-48. Epub 2014/12/03. doi: 10.1016/j.molcel.2014.10.017. PubMed PMID: 25453762.

Kwon H-B, Kozorovitskiy Y, Oh W-J, Peixoto RT, Akhtar N, Saulnier JL, et al. Neuroligin-1–dependent competition regulates cortical synaptogenesis and synapse number. Nature Neuroscience. 2012;15(12):1667-74. doi: 10.1038/nn.3256.

Lande-Diner L, Stewart-Ornstein J, Weitz CJ, Lahav G. Single-cell analysis of circadian dynamics in tissue explants. Mol Biol Cell. 2015;26(22):3940-5. Epub 2015/08/14. doi: 10.1091/mbc.E15-06-0403. PubMed PMID: 26269583; PubMed Central PMCID: PMCPMC4710227.

Lacoste B, Comin CH, Ben-Zvi A, Kaeser PS, Xu X, Costa LdF, et al. Sensory-related neural activity regulates the structure of vascular networks in the cerebral cortex. Neuron. 2014;83(5):1117-30. doi: 10.1016/j.neuron.2014.07.034.

Lee W-CA, Bonin V, Reed M, Graham BJ, Hood G, Glattfelder K, et al. Anatomy and function of an excitatory network in the visual cortex. Nature. 2016;532(7599):370-4. doi: 10.1038/nature17192.

Lehigh KM, West KM, Ginty DD. Retrogradely Transported TrkA Endosomes Signal Locally within Dendrites to Maintain Sympathetic Neuron Synapses. Cell Rep. 2017 Apr 4;19(1):86-100. doi: 10.1016/j.celrep.2017.03.028.

Liao F, Hori Y, Hudry E, Bauer AQ, Jiang H, Mahan TE, et al. Anti-ApoE antibody given after plaque onset decreases Aβ accumulation and improves brain function in a mouse model of Aβ amyloidosis. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2014;34(21):7281-92. doi: 10.1523/JNEUROSCI.0646-14.2014.

Litvina EY, Chen C. Functional Convergence at the Retinogeniculate Synapse. Neuron. 2017 Oct 11;96(2):330-338.e5. doi: 10.1016/j.neuron.2017.09.037.

Litvina EY, Chen C. An Evolving View of Retinogeniculate Transmission. Vis Neurosci. Jan;34:E013. doi: 10.1017/S0952523817000104.

Liu L, Michowski W, Inuzuka H, Shimizu K, Nihira NT, Chick JM, Li N, Geng Y, Meng AY, Ordureau A, Kołodziejczyk A, Ligon KL, Bronson RT, Polyak K, Harper JW, Gygi SP, Wei W, Sicinski P. G1 cyclins link proliferation, pluripotency and differentiation of embryonic stem cells. Nat Cell Biol. 2017 Mar;19(3):177-188. doi: 10.1038/ncb3474.

Lok J, Sardi SP, Guo S, Besancon E, Ha DM, Rosell A, et al. Neuregulin-1 signaling in brain endothelial cells. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2009;29(1):39-43. doi: 10.1038/jcbfm.2008.94.

Maguire CA, Crommentuijn MH, Mu D, Hudry E, Serrano-Pozo A, Hyman BT, et al. Mouse gender influences brain transduction by intravascularly administered AAV9. Molecular therapy : the journal of the American Society of Gene Therapy. 2013;21(8):1470-1. doi: 10.1038/mt.2013.95.

Mandai K, Reimert DV, Ginty DD. Linx Mediates Interaxonal Interactions and Formation of the Internal Capsule. Neuron. 2014;83(1):93-103. doi:10.1016/j.neuron.2014.05.020.

Mao YT, Zhu JX, Hanamura K, Iurilli G, Datta SR, Dalva MB. Filopodia Conduct Target Selection in Cortical Neurons Using Differences in Signal Kinetics of a Single Kinase. Neuron. 2018;98(4):767-82 e8. Epub 2018/05/08. doi: 10.1016/j.neuron.2018.04.011. PubMed PMID: 29731254; PubMed Central PMCID: PMCPMC5987257.

Margolis SS, Salogiannis J, Lipton DM, Mandel-Brehm C, Wills ZP, Mardinly AR, et al. EphB-Mediated Degradation of the RhoA GEF Ephexin5 Relieves a Developmental Brake on Excitatory Synapse Formation. Cell. 2010;143:442-55. doi: 10.1016/j.cell.2010.09.038.

Markowitz JE, Gillis WF, Beron CC, Neufeld SQ, Robertson K, Bhagat ND, et al. The Striatum Organizes 3D Behavior via Moment-to-Moment Action Selection. Cell. 2018. Epub 2018/05/22. doi: 10.1016/j.cell.2018.04.019. PubMed PMID: 29779950.

Merkel SF, Andrews AM, Lutton EM, Mu D, Hudry E, Hyman BT, et al. Trafficking of adeno-associated virus vectors across a model of the blood-brain barrier; a comparative study of transcytosis and transduction using primary human brain endothelial cells. Journal of Neurochemistry. 2017;140(2):216-30. doi: 10.1111/jnc.13861.

Mohideen F, Paulo JA, Ordureau A, Gygi SP, Harper JW. Quantitative Phospho-proteomic Analysis of TNFα/NFκB Signaling Reveals a Role for RIPK1 Phosphorylation in Suppressing Necrotic Cell Death. Mol Cell Proteomics. 2017 Jul;16(7):1200-1216. doi: 10.1074/mcp.M117.068189.

Myre MA, Lumsden AL, Thompson MN, Wasco W, MacDonald ME, Gusella JF. Deficiency of huntingtin has pleiotropic effects in the social amoeba Dictyostelium discoideum. PLoS genetics. 2011;7(4):e1002052-e. doi: 10.1371/journal.pgen.1002052.

Myre MA, Washicosky K, Moir RD, Tesco G, Tanzi RE, Wasco W. Reduced amyloidogenic processing of the amyloid beta-protein precursor by the small-molecule Differentiation Inducing Factor-1. Cellular signalling. 2009;21(4):567-76. doi: 10.1016/j.cellsig.2008.12.008.

Narayanan S, Arthanari H, Wolfe MS, Wagner G. Molecular characterization of disrupted in schizophrenia-1 risk variant S704C reveals the formation of altered oligomeric assembly. The Journal of biological chemistry. 2011;286(51):44266-76. doi: 10.1074/jbc.M111.271593.

Narayanan S, Sato T, Wolfe MS. A C-terminal region of signal peptide peptidase defines a functional domain for intramembrane aspartic protease catalysis. The Journal of biological chemistry. 2007;282(28):20172-9. doi: 10.1074/jbc.M701536200.

Nishitani AM, Ohta S, Yung AR, Del Rio T, Gordon MI, Abraira VE, Avilés EC, Schoenwolf GC, Fekete DM, Goodrich LV. Distinct functions for netrin 1 in chicken and murine semicircular canal morphogenesis. Development. 2017 Sep 15;144(18):3349-3360. doi: 10.1242/dev.144519. 

Oh W-J, Gu C. Establishment of neurovascular congruency in the mouse whisker system by an independent patterning mechanism. Neuron. 2013;80(2):458-69. doi: 10.1016/j.neuron.2013.09.005.

Oh W-J, Gu C. The role and mechanism-of-action of Sema3E and Plexin-D1 in vascular and neural development. Seminars in cell & developmental biology. 2013;24(3):156-62. doi: 10.1016/j.semcdb.2012.12.001.

Ordureau A, Paulo JA, Zhang W, Ahfeldt T, Zhang J, Cohn EF, et al. Dynamics of PARKIN-Dependent Mitochondrial Ubiquitylation in Induced Neurons and Model Systems Revealed by Digital Snapshot Proteomics. Mol Cell. 2018;70(2):211-27 e8. Epub 2018/04/17. doi: 10.1016/j.molcel.2018.03.012. PubMed PMID: 29656925; PubMed Central PMCID: PMCPMC5910199.

Orefice LL, Zimmerman AL, Chirila AM, Sleboda SJ, Head JP, Ginty DD. Peripheral Mechanosensory Neuron Dysfunction Underlies Tactile and Behavioral Deficits in Mouse Models of ASDs Article Peripheral Mechanosensory Neuron Dysfunction Underlies Tactile and Behavioral Deficits in Mouse Models of ASDs. Cell. 2016;166(2):1-15. doi: 10.1016/j.cell.2016.05.033.

Patten BA, Sardi SP, Koirala S, Nakafuku M, Corfas G. Notch1 signaling regulates radial glia differentiation through multiple transcriptional mechanisms. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2006;26(12):3102-8. doi: 10.1523/JNEUROSCI.4829-05.2006.

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